Study on the Application of Doxorubicin-Loaded Magnetic Nanodrugs in Targeted Therapy of Liver Cancer-Reference-Cited by-同舟云学术

Study on the Application of Doxorubicin-Loaded Magnetic Nanodrugs in Targeted Therapy of Liver Cancer

Published:2022-02-22 Issue: Volume:2022 Page:1-7
ISSN:1754-2103
Container-title:Applied Bionics and Biomechanics
language:en
Short-container-title:Applied Bionics and Biomechanics

Author:

Wang Lei¹,Liang Liping¹,Shi Shuzhen¹,Wang Chao²^ORCID

Affiliation:

1. Department of Pharmacy, Qingdao Jiaozhou Central Hospital, Qingdao, 266300 Shandong, China

2. Pharmacy Department of Qingdao Chest Hospital, Qingdao, 266043 Shandong, China

Abstract

Doxorubicin (DOX) has been widely recognized as effective in anticancer therapy; however, the additional organ toxicity and low targeting of DOX in antitumor activity remains unaddressed. The aim of this study was to use the drug carrier dextran/polylactic acid (DEX/PLA) and paramagnetic Fe3O4 to improve the targeting of DOX in liver cancer treatment while reducing its potential organ toxicity. Our experimental results show that the combination drug (Fe3O4@DEX/PLA-DOX) exhibits strong hepatocarcinogenic inhibition and low cytotoxicity and that this modified drug provides a better option for clinical liver cancer treatment.

Publisher

Hindawi Limited

Subject

Biomedical Engineering,Bioengineering,Medicine (miscellaneous),Biotechnology

Link

http://downloads.hindawi.com/journals/abb/2022/2756459.pdf

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