Evaluation of Glycemic and Lipid Profile of Offspring of Diabetic Wistar Rats Treated withMalpighia emarginataJuice-Reference-Cited by-同舟云学术

Evaluation of Glycemic and Lipid Profile of Offspring of Diabetic Wistar Rats Treated withMalpighia emarginataJuice

Published:2011 Issue: Volume:2011 Page:1-6
ISSN:1687-5214
Container-title:Experimental Diabetes Research
language:en
Short-container-title:Experimental Diabetes Research

Author:

Barbalho Sandra M.¹^ORCID,Damasceno Débora C.²,Spada Ana Paula Machado³,Palhares Miréia⁴,Martuchi Karla Aparecida⁵,Oshiiwa Marie⁶,Sazaki Viviane⁴,Silva Vanessa Sellis da⁴

Affiliation:

1. Medical School of Medicine of Marília (UNIMAR), Faculty of Technology and Foods of Marília, Avenida Higino Muzzi Filho, 1001, Marília, SP 17525902, Brazil

2. Laboratory of Experimental Research on Gynecology and Obstetrics, Botucatu Medical School, UNESP, Distrito Rubião Junior, S/N, Botucatu, SP 18618000, Brazil

3. Biochemistry Department, Faculty at UNINOVE and SENAC, USP/São Paulo, SP 01041000, Brazil

4. Nutrition Department, Methodist University of Piracicaba, UNIMEP, Rua Tenente Florencio Pupo Neto, 300, Lins, SP 16400680, Brazil

5. Nutrition Department, Frigorificos Bertin S/A, Rodovia de Acesso Lins-Getulina s/n, Parque Industrial, Lins, SP 16400000, Brazil

6. Faculty of Technology and Foods of Marília, FATEC, Avenida Castro Alves, 62, Marília, SP 17506000, Brazil

Abstract

Knowing that maternal diabetes is related to hyperglycemia and fetal hyperinsulinemia, which affect the lipid metabolism, the aim of this study was to evaluate the effects ofMalpighia emarginata(acerola) juice on the glycemic and lipid profile of offspring of diabetic and nondiabetic Wistar rats. The adult offspring of non-diabetic dams and of dams with severe streptozotocin-induced diabetes were divided into groups: G1, offspring (of control dams) treated with water, G2, offspring (of diabetic dams) treated with water, G3, male offspring (of control dams) treated with acerola juice, and G4, male offspring (of diabetic dams) treated with acerola juice. The offspring of diabetic dams treated with acerola juice showed significantly decreased levels of glucose, cholesterol, triglycerides, and increased HDL-c. The use of acerola juice is a potential strategy to aid in the prevention of DM and dyslipidemia and its complications or to act as an auxiliary in the treatment of these diseases.

Publisher

Hindawi Limited

Subject

General Medicine,Endocrinology, Diabetes and Metabolism

Link

http://downloads.hindawi.com/journals/jdr/2011/173647.pdf

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