Thymus Atrophy and Double-Positive Escape Are Common Features in Infectious Diseases

Author:

de Meis Juliana1,Aurélio Farias-de-Oliveira Désio1,Nunes Panzenhagen Pedro H.1,Maran Naiara2,Villa-Verde Déa Maria Serra1,Morrot Alexandre12,Savino Wilson1

Affiliation:

1. Laboratory on Thymus Research, Oswaldo Cruz Institute, Oswaldo Cruz Foundation, Avenue Brasil 4365, Manguinhos, 21045-900 Rio de Janeiro, RJ, Brazil

2. Department of Immunology, Microbiology Institute, Federal University of Rio de Janeiro, 21941-590 Rio de Janeiro, RJ, Brazil

Abstract

The thymus is a primary lymphoid organ in which bone marrow-derived T-cell precursors undergo differentiation, leading to migration of positively selected thymocytes to the T-cell-dependent areas of secondary lymphoid organs. This organ can undergo atrophy, caused by several endogenous and exogenous factors such as ageing, hormone fluctuations, and infectious agents. This paper will focus on emerging data on the thymic atrophy caused by infectious agents. We present data on the dynamics of thymus lymphocytes during acuteTrypanosoma cruziinfection, showing that the resulting thymus atrophy comprises the abnormal release of thymic-derived T cells and may have an impact on host immune response.

Funder

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior

Publisher

Hindawi Limited

Subject

Infectious Diseases,Parasitology

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