Inflammatory Burden but Not Diabetes Mellitus Influences in Prognosis of Endovascular Revascularization in Peripheral Arterial Disease

Abstract

Aims. To determine the effect of inflammatory preoperative burden on the incidence of reintervention and mortality after endovascular therapy (EVT) and to investigate if diabetes mellitus (DM) is involved in these results. Material and Methods. A prospective cohort study with 12-month follow-up period in patients with peripheral artery disease was carried out. hsCRP and fibrinogen assessments were determined. Results. 85 diabetic and 58 nondiabetic patients were included. An increase between basal hsCRP (11.8 mg/L (10.2; 21.5) versus 4.3 mg/L (1.8; 13.9), P<0.001) and fibrinogen levels (450 mg/dL (425; 479.1) versus 369 mg/dL (268; 419), P<0.001) and the incidence of death during followup was found. A significant increase between higher hsCRP and fibrinogen basal levels and the incidence of reintervention during the follow-up period was also noted (P=0.001 and P=0.04, resp.,). There was no difference between DM and non-DM patients in the 1-year need of reintervention (33.3% versus 45%, P=0.15, resp.,). Basal hsCRP and fibrinogen levels did not significantly differ between DM and non-DM patients who needed reintervention. Conclusions. The prognosis of the EVT is likely marked by the previous inflammatory load, regardless of DM.