Dietary Iron Intake and Serum Ferritin Concentration in 213 Patients Homozygous for theHFEC282YHemochromatosis Mutation

Author:

Gordeuk Victor R1,Lovato Laura2,Barton James C3,Vitolins Mara2,McLaren Gordon4,Acton Ronald T5,McLaren Christine6,Harris Emily L7,Speechley Mark8,Eckfeldt John H9,Diaz Sharmin1,Sholinsky Phyliss10,Adams Paul8

Affiliation:

1. Department of Medicine and Center for Sickle Cell Disease, Howard University, Washington, DC, USA

2. Department of Public Health Sciences, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA

3. Southern Iron Disorders Center, and Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA

4. Veterans Affairs Long Beach Healthcare System, Long Beach, and Division of Hematology/Oncology, Department of Medicine, University of California, Irvine, California, USA

5. Department of Microbiology, University of Alabama at Birmingham, Birmingham, Alabama, USA

6. Department of Epidemiology, University of California, Irvine, California, USA

7. Division of Extramural Research, National Institute of Dental and Craniofacial Research, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, USA

8. Department of Medicine, London Health Sciences Centre, London, Ontario, Canada

9. Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, Minnesota, USA

10. Division of Cardiovascular Sciences, National Heart, Lung, and Blood Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, USA

Abstract

BACKGROUND:HFEC282Yhomozygotes have an increased risk for developing increased iron stores and related disorders. It is controversial whether dietary iron restrictions should be recommended to such individuals.OBJECTIVE: To determine whether dietary iron content influences iron stores inHFEC282Yhomozygotes as assessed by serum ferritin concentration.DESIGN: Serum ferritin concentration was measured and a dietary iron questionnaire was completed as part of the evaluation of 213HFEC282Yhomozygotes who were identified through screening of >100,000 primary care patients at five HEmochromatosis and IRon Overload Screening (HEIRS) Study Field Centers in the United States and Canada.RESULTS: No significant relationships between serum ferritin concentration and dietary heme iron content, dietary nonheme iron content or reports of supplemental iron use were found.CONCLUSION: These results do not support recommending dietary heme or nonheme iron restrictions forHFEC282Yhomozygotes diagnosed through screening in North America.

Publisher

Hindawi Limited

Subject

Gastroenterology,General Medicine

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