Affiliation:
1. Hygiene Section, Department of Biomedical Science and Human Oncology, University of Bari, Piazza G. Cesare 11, 70124 Bari, Italy
Abstract
Although considerable progress has been made in the management of patients with invasive fungal infections,Candidabloodstream infections are still widespread in hospital settings. Incidence rates vary geographically, often because of different patient populations. The aim of the present study was to describe the epidemiology of candidemia, to analyze the trend of species distribution, and to measure thein vitrosusceptibility to antifungal drugs in a university Italian hospital from 1998 to 2013. The antifungal susceptibility for allCandidaisolates was evaluated by broth microdilution assay (CLSI M27-A3 document). Of 394 episodes of candidemia, the average incidence was 3.06/10 000 admissions.C. albicansand non-albicans Candidaspecies caused 44.2% and 55.8% of the episodes, respectively.C. parapsilosis(62.2%) was the most common non-albicans. C. albicanspredominated in almost all departments whereasC. parapsilosiswas found in adult and paediatric oncohaematology units (34.8% and 77.6%, resp.). Overall, mortality occurred in 111 (28.2%) patients. Death occurred most often in intensive care units (47.1%) and specialist surgeries (43.7%). Most of the isolates were susceptible to antifungal drugs, but there was an upward trend for azole (P<0.05). In conclusion, this study emphasizes the importance of monitoring local epidemiologic data and the diversity of patient groups affected.
Subject
General Immunology and Microbiology,General Biochemistry, Genetics and Molecular Biology,General Medicine
Cited by
46 articles.
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