Effect of Warming Yang, Tonifying Kidney, and Removing Arthralgia Therapy on Cold-Dampness Arthralgia Type Ankylosing Spondylitis and Its Influence on the Levels of Humoral Factor in Human Serum

Abstract

Objective. This study is aimed at exploring the effect of warming Yang, tonifying kidney, and removing arthralgia therapy in the treatment of cold-dampness arthralgia type ankylosing spondylitis (AS) and the effects on the levels of humoral factor in human serum. Method. A total of 72 patients with cold-dampness arthralgia type AS treated in our hospital from May 2020 to June 2021 were selected and divided into the observation group ( $n=36$ ) and control group ( $n=36$ ) according to the random number table method. The clinical efficacy of the two groups was observed. The traditional Chinese medicine (TCM) syndrome scores and clinical signs of the two groups were compared, and the pain situation of the two groups was evaluated by visual analog scale (VAS). Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) and Bath Ankylosing Spondylitis Functional Index (BASFI) were used to evaluate the spinal function and activity of the two groups, and the levels of CXC-type chemokine ligand 16 (CXCL16), Dickkopf-1(DKK-1), interleukin-17 (IL-17), tumor necrosis factor-α (TNF-α), sclerostin (SOST) ,and bone morphogenetic protein 2(BMP-2) in serum of the two groups were measured. Results. The total effective rate of the observation group (91.67%) was significantly higher than that of the control group (66.67%) ( $P<0.05$ ). After treatment, the degree of improvement in TCM syndrome score, clinical signs, VAS score, BASDAI, BASFI, and the levels of CXCL16, TNF-α, IL-17, DKK-1, SOST, and BMP-2 in the observation group were significantly higher than that in the control group (all $P<0.05$ ). Conclusion. Warming Yang, tonifying kidney, and removing arthralgia therapy had a good effect on the treatment of cold-dampness arthralgia type AS, and it could effectively improve the clinical symptoms and signs, relieve pain, improve spinal motion, and relieve inflammation of patients.