Involvement of Fibroblast Growth Factor Receptor Genes in Benign Prostate Hyperplasia in a Korean Population

Abstract

Fibroblast growth factors (FGFs) and their receptors (FGFRs) have been implicated in prostate growth and are overexpressed in benign prostatic hyperplasia (BPH). In this study, we investigated whether single nucleotide polymorphisms (SNPs) of theFGFRgenes (FGFR1andFGFR2) were associated with BPH and its clinical phenotypes in a population of Korean men. We genotyped four SNPs in the exons ofFGFR1andFGFR2(rs13317 inFGFR1; rs755793, rs1047100, and rs3135831 inFGFR2) using direct sequencing in 218 BPH patients and 213 control subjects. No SNPs ofFGFR1orFGFR2genes were associated with BPH. However, analysis according to clinical phenotypes showed that rs1047100 ofFGFR2was associated with prostate volume in BPH in the dominant model (GA/AA versus GG,P= 0.010). In addition, a significant association was observed between rs13317 ofFGFR1and international prostate symptom score (IPSS) in the additive (TC versus CC versus TT,P= 0.0022) and dominant models (TC/CC versus TT,P= 0.005). Allele frequency analysis also showed significant association between rs13317 and IPSS (P= 0.005). These results suggested thatFGFRgenes could be related to progression of BPH.