Characteristics of HLA-E Restricted T-Cell Responses and Their Role in Infectious Diseases-Reference-Cited by-同舟云学术

Characteristics of HLA-E Restricted T-Cell Responses and Their Role in Infectious Diseases

Published:2016 Issue: Volume:2016 Page:1-11
ISSN:2314-8861
Container-title:Journal of Immunology Research
language:en
Short-container-title:Journal of Immunology Research

Author:

Joosten Simone A.¹^ORCID,Sullivan Lucy C.²^ORCID,Ottenhoff Tom H. M.¹

Affiliation:

1. Department of Infectious Diseases, Leiden University Medical Center, 2333 ZA Leiden, Netherlands

2. Department of Microbiology and Immunology, The University of Melbourne, Peter Doherty Institute for Infection and Immunity, Melbourne, VIC 3010, Australia

Abstract

Human HLA-E can, in addition to self-antigens, also present pathogen-derived sequences, which elicit specific T-cell responses. T-cells recognize their antigen presented by HLA-E highly specifically and have unique functional and phenotypical properties. Pathogen specific HLA-E restricted CD8+T-cells are an interesting new player in the field of immunology. Future work should address their exact roles and relative contributions in the immune response against infectious diseases.

Publisher

Hindawi Limited

Subject

Immunology,General Medicine,Immunology and Allergy

Link

http://downloads.hindawi.com/journals/jir/2016/2695396.pdf

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