Clinical Considerations ofBRCA1- andBRCA2-Mutation Carriers: A Review-Reference-Cited by-同舟云学术

Clinical Considerations ofBRCA1- andBRCA2-Mutation Carriers: A Review

Published:2011 Issue: Volume:2011 Page:1-11
ISSN:2090-1402
Container-title:International Journal of Surgical Oncology
language:en
Short-container-title:International Journal of Surgical Oncology

Author:

Bougie O.¹,Weberpals J. I.²³

Affiliation:

1. The Department of Obstetrics, Gynaecology, and Newborn Care, The Ottawa Hospital, Ottawa, ON, Canada K1H 8L6

2. Centre for Cancer Therapeutics, Ottawa Hospital Research Institute, The Ottawa Hospital, Ottawa, ON, Canada K1H 8L6

3. The Division of Gynaecologic Oncology, The Ottawa Hospital, Ottawa, ON, Canada K1H 8L6

Abstract

Individuals who carry an inherited mutation in the breast cancer 1 (BRCA1) andBRCA2genes have a significant risk of developing breast and ovarian cancer over the course of their lifetime. As a result, there are important considerations for the clinician in the counseling, followup and management of mutation carriers. This review outlines salient aspects in the approach to patients at high risk of developing breast and ovarian cancer, including criteria for genetic testing, screening guidelines, surgical prophylaxis, and chemoprevention.

Funder

Ottawa Regional Cancer Foundation

Publisher

Hindawi Limited

Subject

Oncology,Surgery

Link

http://downloads.hindawi.com/journals/ijso/2011/374012.pdf

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