In Vitro Antibacterial and Antifungal Potential of Amyrin-Type Triterpenoid Isolated from Datura metel Linnaeus

Author:

Bawazeer Sami1ORCID,Rauf Abdur2ORCID

Affiliation:

1. Department of Pharmacognosy, Faculty of Pharmacy, Umm Al-Qura University, Makkah, P.O. Box 42, Saudi Arabia

2. Department of Chemistry, University of Swabi, Swabi, KPK, Pakistan

Abstract

The aim of the present investigation was to evaluate the effect of the combined crude extract, fractions, and compound 1 isolated from the fruits of Datura metel against selected microbial (bacteria and fungi) strains. Results of antibacterial screening indicated marked susceptibility of the extract and its fractions against tested bacterial strains. Among the extract and various fractions, the chloroform fraction exhibited a significant effect against different bacterial strains including Escherichia coli, Staphylococcus aureus, and Bacillus subtilis with an inhibitory zone ranging from 18 to 24 mm. Similarly, results of antifungal activity revealed that the chloroform fraction displays a promising effect against various fungal strains. The chloroform fraction was subjected to repeated chromatography analysis, which yielded compound 1 (daturaolone). Daturaolone exhibited potent activity against selected bacterial strains including Klebsiella pneumoniae, B. subtilis, S. epidermidis, and S. aureus with an inhibitory zone ranging from 12 to 30 mm. In addition, the extracts and daturaolone exhibited significant sensitivity against T. longifusus, C. albicans, A. flavus, M. canis, F. solani, and C. glabrata. Taken all together, it is concluded that our findings validated the traditional use of D. metel to treat various infectious diseases, which is supported by daturaolone.

Funder

King Abdulaziz City for Science and Technology

Publisher

Hindawi Limited

Subject

General Immunology and Microbiology,General Biochemistry, Genetics and Molecular Biology,General Medicine

Reference21 articles.

1. In Vivo Anti-inflammatory, Analgesic, and Sedative Studies of the Extract and Naphthoquinone Isolated from Diospyros kaki (Persimmon)

2. Review on Datura metel: a potential medicinal plant;M. M. Khaton;Global Journal of Research on Medicinal Plants and Indigenous Medicine,2012

3. A novel antifungal pyrrole derivative from Datura metel leaves;R. Dabur;Die Pharmazie-An International Journal of Pharmaceutical Sciences,2004

4. The tonoplast, a specific marker of embryogenic microspores of Datura cultured in vitro

5. Isolation, characterization and antibacterial activity of alkaloid from Datura metel Linn leaves;D. E. Okwu;African Journal of Pharmacology,2009

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