A Survey of the Use of Iterative Reconstruction Algorithms in Electron Microscopy

Author:

Sorzano C. O. S.12ORCID,Vargas J.1ORCID,Otón J.1,de la Rosa-Trevín J. M.1ORCID,Vilas J. L.1,Kazemi M.1,Melero R.1,del Caño L.1,Cuenca J.1,Conesa P.1,Gómez-Blanco J.1,Marabini R.3,Carazo J. M.1

Affiliation:

1. Centro Nacional de Biotecnología, CSIC, c/Darwin 3, Cantoblanco, 28049 Madrid, Spain

2. Universidad CEU San Pablo, Campus Urbanizacion Montepríncipe, Boadilla del Monte, 28668 Madrid, Spain

3. Universidad Autónoma de Madrid, Cantoblanco, 28049 Madrid, Spain

Abstract

One of the key steps in Electron Microscopy is the tomographic reconstruction of a three-dimensional (3D) map of the specimen being studied from a set of two-dimensional (2D) projections acquired at the microscope. This tomographic reconstruction may be performed with different reconstruction algorithms that can be grouped into several large families: direct Fourier inversion methods, back-projection methods, Radon methods, or iterative algorithms. In this review, we focus on the latter family of algorithms, explaining the mathematical rationale behind the different algorithms in this family as they have been introduced in the field of Electron Microscopy. We cover their use in Single Particle Analysis (SPA) as well as in Electron Tomography (ET).

Funder

Comunidad de Madrid

Publisher

Hindawi Limited

Subject

General Immunology and Microbiology,General Biochemistry, Genetics and Molecular Biology,General Medicine

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