Abnormal Cell Responses and Role of TNF-αin Impaired Diabetic Wound Healing-Reference-Cited by-同舟云学术

Abnormal Cell Responses and Role of TNF-αin Impaired Diabetic Wound Healing

Published:2013 Issue: Volume:2013 Page:1-9
ISSN:2314-6133
Container-title:BioMed Research International
language:en
Short-container-title:BioMed Research International

Author:

Xu Fanxing¹²,Zhang Chenying²³,Graves Dana T.²

Affiliation:

1. School of Life Science and Biotechnology, Dalian University of Technology, Dalian 116024, China

2. Department of Periodontics, School of Dental Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA

3. Department of Preventive Dentistry, School and Hospital of Stomatology, Peking University, Beijing 100081, China

Abstract

Impaired diabetic wound healing constitutes a major health problem. The impaired healing is caused by complex factors such as abnormal keratinocyte and fibroblast migration, proliferation, differentiation, and apoptosis, abnormal macrophage polarization, impaired recruitment of mesenchymal stem cells (MSCs) and endothelial progenitor cells (EPCs), and decreased vascularization. Diabetes-enhanced and prolonged expression of TNF-αalso contributes to impaired healing. In this paper, we discuss the abnormal cell responses in diabetic wound healing and the contribution of TNF-α.

Funder

NIDCR

Publisher

Hindawi Limited

Subject

General Immunology and Microbiology,General Biochemistry, Genetics and Molecular Biology,General Medicine

Link

http://downloads.hindawi.com/journals/bmri/2013/754802.pdf

Reference106 articles.

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2. Economic Costs of Diabetes in the U.S. in 2007

3. Wound Repair and Regeneration