Synthesis and Antifungal Activity of β-Hydroxysulfides of 1,3-Dioxepane Series-Reference-Cited by-同舟云学术

Synthesis and Antifungal Activity of β-Hydroxysulfides of 1,3-Dioxepane Series

Published:2018-10-10 Issue: Volume:2018 Page:1-14
ISSN:2090-9063
Container-title:Journal of Chemistry
language:en
Short-container-title:Journal of Chemistry

Author:

Pavelyev Roman S.¹^ORCID,Vafina Rusalia M.¹,Balakin Konstantin V.¹²^ORCID,Gnezdilov Oleg I.³,Dobrynin Aleksey B.⁴,Lodochnikova Olga A.⁴^ORCID,Musin Rashid Z.⁴,Chmutova Galina A.¹,Lisovskaya Svetlana A.⁵^ORCID,Nikitina Liliya E.⁶

Affiliation:

1. Kazan (Volga Region) Federal University, Kremlyovskaya 18, Kazan 420008, Russia

2. I.M. Sechenov First Moscow State Medical University, Trubetskaya 8, Bldg 2, Moscow 119991, Russia

3. Kazan E. K. Zavoisky Physical-Technical Institute of the Russian Academy of Sciences, Sibirsky Tract, 10/7, Kazan 420029, Russia

4. A.E. Arbuzov Institute of Organic and Physical Chemistry; KazSC, Russian Academy of Sciences, Arbuzova 8, Kazan 420088, Russia

5. Kazan Scientific and Research Institute of Epidemiology and Microbiology, Bolshaya Krasnaya 67, Kazan 420015, Russia

6. Kazan State Medical University, Butlerova 49, Kazan 420012, Russia

Abstract

Synthesis of β-hydroxysulfides of 1,3-dioxepane series and their further functionalization were performed. Chiral β-hydroxysulfides were separated into enantiomers using enzymatic acylation by lipase PS. Study of antifungal activity of the obtained compounds showed that some enantiomerically pure 6-arylthio-1,3-dioxepan-5-ols represent promising antifungal drug candidates.

Funder

Programs of Competitive Growth of Kazan (Volga region) Federal University

Publisher

Hindawi Limited

Subject

General Chemistry

Link

http://downloads.hindawi.com/journals/jchem/2018/3589342.pdf

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