Affiliation:
1. Department of Chemistry, IPGG (PG) College of Commerce Haldwani, Nainital (263139), Kumaun University Nainital, Uttarakhand, India
Abstract
New antibacterial ligand H3hmbpa-5 (N-(2-hydroxy-5-methyl benzyl)phenylalanine) and its aluminium complexes Al(OPri)(Hhmbpa-5), Al(H2hmbpa-5)(Hhmbpa-5), and Al(H2hmbpa-5)3 were synthesized in excellent yield in a stoichiometric ratio of 1 : 1, 1 : 2, and 1 : 3 (Al(OPri)3 : ligand), based on an idea of biological activity of the phenylalanine and its substituted N-aryl derivatives and Al (III) derivatives. The complexes were characterized by FT-IR, 1H, 13C NMR, UV-visible, and elemental analysis. An inhibition zone test was used for the evaluation of the antibacterial test. The results show that the ligand and aluminium complexes have superior antibacterial activity against Pseudomonas aeruginosa (MTCC-424), Streptococcus aureus (MTCC-103), Klebsiella pneumoniae (MTCC-3389), and Klebsiella pneumoniae (MTCC-109).