MicroRNA-Mediated Regulation of HMGB1 in Human Hepatocellular Carcinoma-Reference-Cited by-同舟云学术

MicroRNA-Mediated Regulation of HMGB1 in Human Hepatocellular Carcinoma

Published:2018 Issue: Volume:2018 Page:1-10
ISSN:2314-6133
Container-title:BioMed Research International
language:en
Short-container-title:BioMed Research International

Author:

Yan Jianing¹^ORCID,Ying Shibo²^ORCID,Cai Xiujun¹^ORCID

Affiliation:

1. Department of General Surgery, Sir Run Run Shaw Hospital Affiliated to Medical College of Zhejiang University, Hangzhou 310016, China

2. Institute of Occupational Diseases, Zhejiang Academy of Medical Sciences, Hangzhou 310013, China

Abstract

High-mobility group box 1 (HMGB1) is a potential therapeutic target and novel biomarker in a variety of malignant tumors, including hepatocellular carcinoma (HCC). More recently, a number of microRNAs (miRNAs) are identified as a class of regulators for broad control of HMGB1-mediated biological actions in eukaryotic cells. In this review article we will describe representative miRNAs involved in regulating the HMGB1 signaling pathways in HCC cell lines and/or animal models. We also propose the possible mechanisms underlying the miRNA/HMGB1 axis and discuss the future clinical significance of miRNAs targeting HMGB1 molecule for HCC therapy.

Funder

National Natural Science Foundation of China

Publisher

Hindawi Limited

Subject

General Immunology and Microbiology,General Biochemistry, Genetics and Molecular Biology,General Medicine

Link

http://downloads.hindawi.com/journals/bmri/2018/2754941.pdf

Reference105 articles.

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