Assessment of Serum Tumor Markers for Predicting Ocular Metastasis in Lung Adenocarcinoma: A Retrospective Study

Author:

Shi Wen-Qing1,Liu Wen-Feng2ORCID,Li Biao1,Lin Qi1,Li Qing-Hai1,Zhang Yu-Qing1,Yuan Qing1,Liang Rong-Bin1,Ge Qian-Min1,Shao Yi1ORCID

Affiliation:

1. Department of Ophthalmology, The First Affiliated Hospital of Nanchang University, Jiangxi Province Clinical Ophthalmology Institute, Nanchang, 330006 Jiangxi, China

2. Department of Hepatic Oncology, Zhongshan Hospital, Fudan University, Shanghai 200032, China

Abstract

The purpose of this study was to detect clinical variations between lung adenocarcinoma patients with and without ocular metastasis (OM) to identify risk factors for OM and assess the diagnostic values. We included 1153 patients with lung adenocarcinoma in this study. Independent t-tests and chi-square tests were used to compare patients’ clinical characteristics. Statistically significant parameters were analyzed by binary logistic regression to detect risk factors of OM. The results showed that the OM group had increased alpha-fetoprotein (AFP), carcinoembryonic antigen (CEA), cytokeratin fragment 19 (CYFRA 21-1), carbohydrate antigen- (CA-) 125, CA-153, and total prostate-specific antigen (TPSA) compared with the NOM group. CYFRA21-1 is the most useful biomarker for detecting OM in this population.

Funder

Natural Science Key Project of Jiangxi Province

Publisher

Hindawi Limited

Subject

Biochemistry, medical,Clinical Biochemistry,Genetics,Molecular Biology,General Medicine

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