Isolation and Characterisation of Mesenchymal Stem Cells from Different Regions of the Human Umbilical Cord-Reference-Cited by-同舟云学术

Isolation and Characterisation of Mesenchymal Stem Cells from Different Regions of the Human Umbilical Cord

Published:2013 Issue: Volume:2013 Page:1-8
ISSN:2314-6133
Container-title:BioMed Research International
language:en
Short-container-title:BioMed Research International

Author:

Mennan Claire¹,Wright Karina¹,Bhattacharjee Atanu²,Balain Birender²,Richardson James²,Roberts Sally¹

Affiliation:

1. The Robert Jones and Agnes Hunt Orthopaedic Hospital NHS Foundation Trust & ISTM, Keele University, Oswestry, Shropshire SY10 7AG, UK

2. Institute for Orthopaedics, The Robert Jones & Agnes Hunt Orthopaedic Hospital NHS Foundation Trust, Oswestry SY10 7AG, UK

Abstract

Umbilical cords as a source of stem cells are of increasing interest for cell therapies as they present little ethical consideration and are reported to contain immune privileged cells which may be suitable for allogeneic based therapies. Mesenchymal stem cells (MSCs) sourced from several different cord regions, including artery, vein, cord lining, and Wharton’s jelly, are described in the literature. However, no one study has yet isolated and characterised MSCs from all regions of the same cord to determine the most suitable cells for cell based therapeutics.

Funder

Arthritis Research UK

Publisher

Hindawi Limited

Subject

General Immunology and Microbiology,General Biochemistry, Genetics and Molecular Biology,General Medicine

Link

http://downloads.hindawi.com/journals/bmri/2013/916136.pdf

Reference24 articles.

1. Phenotype and Differentiation Potential of Stromal Populations Obtained from Various Zones of Human Umbilical Cord: An Overview

2. Replicative senescence of human bone marrow and umbilical cord derived mesenchymal stem cells and their differentiation to adipocytes and osteoblasts

3. Native Umbilical Cord Matrix Stem Cells Express Hepatic Markers and Differentiate Into Hepatocyte-like Cells