Design and Microwave Assisted Synthesis of Coumarin Derivatives as PDE Inhibitors-Reference-Cited by-同舟云学术

Design and Microwave Assisted Synthesis of Coumarin Derivatives as PDE Inhibitors

Published:2016-02-21 Issue: Volume:2016 Page:1-16
ISSN:2090-2069
Container-title:International Journal of Medicinal Chemistry
language:en
Short-container-title:International Journal of Medicinal Chemistry

Author:

Kumbar Mahadev N.¹,Kamble Ravindra R.¹,Kamble Atulkumar A.¹,Salian Sujith Raj²,Kumari Sandhya²,Nair Ramya²,Kalthur Guruprasad²,Adiga Satish Kumar²,Prasad D. Jagadeesh³

Affiliation:

1. Department of Chemistry, Karnatak University, Pavate Nagar, Dharwad 580003, India

2. Centre of Excellence in Clinical Embryology, Level 2, Central Research Lab, Kasturba Medical College, Manipal University, Manipal, Karnataka 576104, India

3. Department of Studies in Chemistry, Mangalore University, Konaje, Karnataka 574199, India

Abstract

Coumarins appended to benzimidazole through pyrazole are designed and synthesized using microwave irradiation. These compounds were analyzed for phosphodiesterase (PDE) inhibition indirectly by motility pattern in human spermatozoa. Some of the synthesized compounds, namely, 5d, 5e, 5f, 5g, 5h, and 5k, have exhibited potent inhibitory activity on PDE.

Funder

University Grants Commission

Publisher

Hindawi Limited

Subject

Drug Discovery,Molecular Medicine,Biochemistry

Link

http://downloads.hindawi.com/archive/2016/9890630.pdf

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