Identification of Age-Related Macular Degeneration Related Genes by Applying Shortest Path Algorithm in Protein-Protein Interaction Network-Reference-Cited by-同舟云学术

Identification of Age-Related Macular Degeneration Related Genes by Applying Shortest Path Algorithm in Protein-Protein Interaction Network

Published:2013 Issue: Volume:2013 Page:1-8
ISSN:2314-6133
Container-title:BioMed Research International
language:en
Short-container-title:BioMed Research International

Author:

Zhang Jian¹,Jiang Min²,Yuan Fei²,Feng Kai-Yan³,Cai Yu-Dong⁴,Xu Xun¹,Chen Lei⁵

Affiliation:

1. Department of Ophthalmology, Shanghai First People’s Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai 200080, China

2. State Key Laboratory of Medical Genomics, Institute of Health Sciences, Shanghai Jiaotong University School of Medicine and Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200025, China

3. Beijing Genomics Institute, Shenzhen Beishan Industrial Zone, Shenzhen 518083, China

4. Institute of Systems Biology, Shanghai University, Shanghai 200444, China

5. College of Information Engineering, Shanghai Maritime University, Shanghai 201306, China

Abstract

This study attempted to find novel age-related macular degeneration (AMD) related genes based on 36 known AMD genes. The well-known shortest path algorithm, Dijkstra’s algorithm, was applied to find the shortest path connecting each pair of known AMD related genes in protein-protein interaction (PPI) network. The genes occurring in any shortest path were considered as candidate AMD related genes. As a result, 125 novel AMD genes were predicted. The further analysis based on betweenness and permutation test indicates that there are 10 genes involved in the formation or development of AMD and may be the actual AMD related genes with high probability. We hope that this contribution would promote the study of age-related macular degeneration and discovery of novel effective treatments.

Funder

National Natural Science Foundation of China

Publisher

Hindawi Limited

Subject

General Immunology and Microbiology,General Biochemistry, Genetics and Molecular Biology,General Medicine

Link

http://downloads.hindawi.com/journals/bmri/2013/523415.pdf

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3. Treatment of age-related macular degeneration

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