Diagnostic Value of Adenosine Deaminase and Its Isoforms in Type II Diabetes Mellitus-Reference-Cited by-同舟云学术

Diagnostic Value of Adenosine Deaminase and Its Isoforms in Type II Diabetes Mellitus

Published:2016-12-05 Issue: Volume:2016 Page:1-6
ISSN:2090-0406
Container-title:Enzyme Research
language:en
Short-container-title:Enzyme Research

Author:

Larijani Bagher¹,Heshmat Ramin²,Ebrahimi-Rad Mina³,Khatami Shohreh³,Valadbeigi Shirin³,Saghiri Reza³^ORCID

Affiliation:

1. Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran

2. Chronic Diseases Research Center, Endocrinology and Metabolism Population Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran

3. Department of Biochemistry, Pasteur Institute of Iran, Tehran, Iran

Abstract

Background and Aims. In the present study, we have investigated the activity of adenosine deaminase (ADA) as a diagnostic marker in type 2 (or II) diabetes mellitus (T2DM). Design and Methods. The deaminase activity of ADA1 and ADA2 was determined in serum from 33 patients with type 2 (or II) diabetes mellitus and 35 healthy controls. We also determined the proportion of glycated hemoglobin (HbA1c). Results. Our results showed significant differences between total serum ADA (tADA) and ADA2 activities in the diabetic groups with HbA1c < 8 (%) and HbA1c ≥ 8 (%) with respect to the values in healthy individuals (p<0.001). ADA2 activity in patients with high HbA1c was found to be much higher than that in patients with low HbA1c (p=0.0001). In addition, total ADA activity showed a significant correlation with HbA1c (r=0.6, p<0.0001). Conclusions. Total serum ADA activity, specially that due to ADA2, could be useful test for the diagnosis of type 2 (or II) diabetes mellitus.

Funder

Endocrinology and Metabolism Research Institute

Publisher

Hindawi Limited

Subject

Molecular Biology,Biochemistry

Link

http://downloads.hindawi.com/archive/2016/9526593.pdf

Reference39 articles.

1. Associations of cardiorespiratory fitness and parental history of diabetes with risk of type 2 diabetes

2. Guidelines for the management of type 2 diabetes: is ADA and EASD consensus more clinically relevant than the IDF recommendations?

3. Presence of adenosine deaminase on the surface of mononuclear blood cells: immunochemical localization using light and electron microscopy.