How the Interval between Prime and Boost Injection Affects the Immune Response in a Computational Model of the Immune System-Reference-Cited by-同舟云学术

How the Interval between Prime and Boost Injection Affects the Immune Response in a Computational Model of the Immune System

Published:2012 Issue: Volume:2012 Page:1-9
ISSN:1748-670X
Container-title:Computational and Mathematical Methods in Medicine
language:en
Short-container-title:Computational and Mathematical Methods in Medicine

Author:

Castiglione F.¹,Mantile F.²,De Berardinis P.³,Prisco A.²

Affiliation:

1. Institute for Computing Applications “M. Picone”, National Research Council of Italy, via dei Taurini 19, 00185 Roma, Italy

2. Institute of Genetics and Biophysics “A. Buzzati Traverso”, National Research Council of Italy, via Pietro Castellino 111, 08013 Naples, Italy

3. Institute of Protein Biochemistry National Research Council of Italy, via Pietro Castellino 111, 08013 Naples, Italy

Abstract

The immune system is able to respond more vigorously to the second contact with a given antigen than to the first contact. Vaccination protocols generally include at least two doses, in order to obtain high antibody titers. We want to analyze the relation between the time elapsed from the first dose (priming) and the second dose (boost) on the antibody titers. In this paper, we couplein vivoexperiments with computer simulations to assess the effect of delaying the second injection. We observe that an interval of several weeks between the prime and the boost is necessary to obtain optimal antibody responses.

Publisher

Hindawi Limited

Subject

Applied Mathematics,General Immunology and Microbiology,General Biochemistry, Genetics and Molecular Biology,Modelling and Simulation,General Medicine

Link

http://downloads.hindawi.com/journals/cmmm/2012/842329.pdf

Reference38 articles.

1. ANTIGEN-SPECIFIC MEMORY B CELL DEVELOPMENT

2. Memory B and memory plasma cells

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