Icariin Promotes the Migration of BMSCs In Vitro and In Vivo via the MAPK Signaling Pathway

Author:

Jiao Feng1ORCID,Tang Wang2,Huang He1,Zhang Zhaofei1,Liu Donghua1,Zhang Hongyi1,Ren Hui3

Affiliation:

1. Guangzhou Hospital of Integrated Traditional and Western Medicine, China

2. Guangzhou University of Chinese Medicine, China

3. The First Affiliated Hospital of Guangzhou University of Traditional Chinese Medicine, China

Abstract

Bone marrow-derived mesenchymal stem cells (BMSCs) are widely used in tissue engineering for regenerative medicine due to their multipotent differentiation potential. However, their poor migration ability limits repair effects. Icariin (ICA), a major component of the Chinese medical herb Herba Epimedii, has been reported to accelerate the proliferation, osteogenic, and chondrogenic differentiation of BMSCs. However, it remains unknown whether ICA can enhance BMSC migration, and the possible underlying mechanisms need to be elucidated. In this study, we found that ICA significantly increased the migration capacity of BMSCs, with an optimal concentration of 1 μmol/L. Moreover, we found that ICA stimulated actin stress fiber formation in BMSCs. Our work revealed that activation of the MAPK signaling pathway was required for ICA-induced migration and actin stress fiber formation. In vivo, ICA promoted the recruitment of BMSCs to the cartilage defect region. Taken together, these results show that ICA promotes BMSC migration in vivo and in vitro by inducing actin stress fiber formation via the MAPK signaling pathway. Thus, combined administration of ICA with BMSCs has great potential in cartilage defect therapy.

Funder

Traditional Chinese Medicine Bureau of Guangdong Province

Publisher

Hindawi Limited

Subject

Cell Biology,Molecular Biology

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