Colonic Mucosal Epigenome and Microbiome Development in Children and Adolescents-Reference-Cited by-同舟云学术

Colonic Mucosal Epigenome and Microbiome Development in Children and Adolescents

Published:2016 Issue: Volume:2016 Page:1-7
ISSN:2314-8861
Container-title:Journal of Immunology Research
language:en
Short-container-title:Journal of Immunology Research

Author:

Harris R. Alan¹,Shah Rajesh²,Hollister Emily B.³⁴,Tronstad Rune Rose⁵⁶,Hovdenak Nils⁷,Szigeti Reka³,Versalovic James³⁴,Kellermayer Richard⁴⁸⁹

Affiliation:

1. Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA

2. Section of Gastroenterology and Hepatology, Baylor College of Medicine, Houston, TX 77030, USA

3. Department of Pathology & Immunology, Baylor College of Medicine, Houston, TX 77030, USA

4. Texas Children’s Hospital, Houston, TX 77030, USA

5. Department of Clinical Science, University of Bergen, 5020 Bergen, Norway

6. Department of Pediatrics, Haukeland University Hospital, 5021 Bergen, Norway

7. Department of Clinical Medicine, University of Bergen, 5020 Bergen, Norway

8. Section of Pediatric Gastroenterology, Department of Pediatrics, Baylor College of Medicine, Houston, TX 77030, USA

9. USDA/ARS Children’s Nutrition Research Center, Houston, TX 77030, USA

Abstract

Epigenetic and microbiome changes during pediatric development have been implicated as important elements in the developmental origins of inflammatory bowel diseases (IBDs) including Crohn’s disease (CD) and ulcerative colitis (UC), which are linked to early onset colorectal cancer (CRC). Colonic mucosal samples from 22 control children between 3.5 and 17.5 years of age were studied by Infinium HumanMethylation450 BeadChips and, in 10 cases, by 454 pyrosequencing of the bacterial16S rRNAgene. Intercalating age-specific DNA methylation and microbiome changes were identified, which may have significant translational relevance in the developmental origins of IBD and CRC.

Funder

National Institutes of Health

Publisher

Hindawi Limited

Subject

Immunology,General Medicine,Immunology and Allergy

Link

http://downloads.hindawi.com/journals/jir/2016/9170162.pdf

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