Advances in Chemical Synthesis of Fondaparinux-Reference-Cited by-同舟云学术

Advances in Chemical Synthesis of Fondaparinux

Published:2019-05-12 Issue: Volume:2019 Page:1-17
ISSN:2090-9063
Container-title:Journal of Chemistry
language:en
Short-container-title:Journal of Chemistry

Author:

Ding Yili¹^ORCID,Vara Prasad Chamakura V. N. S.²^ORCID,Wang Bingyun¹^ORCID

Affiliation:

1. Life Science Department, Foshan University, Foshan, Guangdong 528000, China

2. Das Pharma, Turangi P.O., Kakinada, AP 533016, India

Abstract

Fondaparinux (trade name Arixtra) is a safe and efficacious anticoagulant, and it is chemically related to low-molecular-weight heparins such as enoxaparin. Fondaparinux is a synthetic pentasaccharide, and its synthesis is difficult and expensive. The high cost of fondaparinux thwarts its extensive worldwide usage. Over the last two decades, several research groups and pharmaceutical companies have been interested in finding efficient and practical methods for its synthesis. The present review discusses those strategies and their pros and cons in a comparative account.

Funder

Department of Education of Guangdong Province

Publisher

Hindawi Limited

Subject

General Chemistry

Link

http://downloads.hindawi.com/journals/jchem/2019/9545297.pdf

Reference34 articles.

1. Dissection of heparin - past and future

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1. A review on multifaceted biomedical applications of heparin nanocomposites: Progress and prospects;International Journal of Biological Macromolecules;2024-03

2. Fondaparinux Sodium: Recent Advances in the Management of Thrombosis;Journal of Cardiovascular Pharmacology and Therapeutics;2023-01-01

3. Synthesis of Uronic Acid Containing Oligosaccharides;Comprehensive Glycoscience;2021