Changing Interdigestive Migrating Motor Complex in Rats under Acute Liver Injury-Reference-Cited by-同舟云学术

Changing Interdigestive Migrating Motor Complex in Rats under Acute Liver Injury

Published:2014 Issue: Volume:2014 Page:1-7
ISSN:2314-6133
Container-title:BioMed Research International
language:en
Short-container-title:BioMed Research International

Author:

Liu Mei¹²^ORCID,Zheng Su-Jun¹,Xu Weihong³,Zhang Jianying²,Chen Yu¹,Duan Zhongping¹

Affiliation:

1. Artificial Liver Center, Beijing You’an Hospital, Capital Medical University, Beijing 100069, China

2. Department of Biological Sciences, The University of Texas at El Paso, El Paso, TX 79968, USA

3. Department of Rheumatology, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310009, China

Abstract

Gastrointestinal motility disorder is a major clinical manifestation of acute liver injury, and interdigestive migrating motor complex (MMC) is an important indicator. We investigated the changes and characteristics of MMC in rats with acute liver injury. Acute liver injury was created byD-galactosamine, and we recorded the interdigestive MMC using a multichannel physiological recorder and compared the indexes of interdigestive MMC. Compared with normal controls, antral MMC Phase I duration was significantly prolonged and MMC Phase III duration was significantly shortened in the rats with acute liver injury. The duodenal MMC cycle and MMC Phases I and IV duration were significantly prolonged and MMC Phase III duration was significantly shortened in the rats with acute liver injury. The jejunal MMC cycle and MMC Phases I and IV duration were significantly prolonged and MMC Phase III duration was significantly shortened in the rats with acute liver injury compared with normal controls. Compared with the normal controls, rats with acute liver injury had a significantly prolonged interdigestive MMC cycle, related mainly to longer MMC Phases I and IV, shortened MMC Phase III, and MMC Phase II characterized by increased migrating clustered contractions, which were probably major contributors to the gastrointestinal motility disorders.

Funder

You’an liver disease and AIDS funds

Publisher

Hindawi Limited

Subject

General Immunology and Microbiology,General Biochemistry, Genetics and Molecular Biology,General Medicine

Link

http://downloads.hindawi.com/journals/bmri/2014/634281.pdf

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