In VivoLipid Regulation Mechanism of Polygoni Multiflori Radix in High-Fat Diet Fed Rats

Author:

Lin Pei1,He Yan Ran1,Lu Jian Mei1,Li Na1,Wang Wan Gen1,Gu Wen1,Yu Jie1,Zhao Rong Hua1

Affiliation:

1. Yunnan University of Traditional Chinese Medicine, Kunming, Yunnan 650500, China

Abstract

Mechanisms of the water extracts of Polygoni Multiflori Radix (PMR) and its processed products (PMRP) on liver lipid metabolism were observed in this paper. Aqueous extract of PMR and PMRP was given to nonalcoholic fatty liver model rats, respectively. PMR was better in reducing the contents of very low density lipoprotein (VLDL) than PMRP and the positive control groups. In the aspect of regulating TG, medium dose PMR reduced the activity of diacylglycerol acyltransferase (DGAT) to1536±47.69 pg/mL (P<0.001) and promoted the expression of hepatic lipase (HL) to23.59±0.2758 U/mL (P<0.05). HL promotion ability of medium dose PMR was similar with the simvastatin positive control. Both medium and high dose of PMR showed significant alterations in TC, which were related to the downregulation effects on hydroxyl methyl-glutaryl coenzyme A reductase (HMGCR) and upregulation effects on cholesterol 7-alpha-hydroxylase or cytochrome P450 7A (CYP7A). Quantitative relationships research indicated that the prominent effect on inhibiting the content of HMGCR (r=0.756,P<0.05) was strongly positive correlated with to the TC regulation effects. Effects of PMR on enhancing decomposition rate or reducingde novosynthesis rate of TG and TC were better than PMRP.

Funder

National Natural Science Foundation of China

Publisher

Hindawi Limited

Subject

Complementary and alternative medicine

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