Affiliation:
1. Department of Biology, College of Sciences, Jazan University, P.O. Box 2079, Jazan 45142, Saudi Arabia
2. Department of Biology, College of Science, Imam Abdulrahman Bin Faisal University, P. O. Box 383, Dammam 31113, Saudi Arabia
3. Basic and Applied Scientific Research Center (BASRC), Imam Abdulrahman Bin Faisal University, P.O. Box 1982, Dammam 31441, Saudi Arabia
4. Department of Physics, College of Science, Imam Abdulrahman Bin Faisal University, P.O. Box 1982, Dammam 31441, Saudi Arabia
Abstract
Silver nanoparticles (Ag-NPs) have been used in medical, agricultural, and industrial purposes. Furthermore, NPs can cross the blood-brain barrier and encourage some effects on spatial learning and memory in organism. Here, we investigate the possible neurotoxicity of Ag-NPs with special emphasis on the neuroprotective impacts of yttrium-oxide nanoparticles (YO-NPs) in male mice. Male mice (
) were weekly intraperitoneally injected for 35 days as the following; groups I, II, III, and IV received tap water (control), Ag-NPs (40 mg/kg), YO-NPs (40 mg/kg), and Ag-NPs/YO-NPs (40 mg/kg each), respectively. After that, animals were tested in shuttle box, Morris water-maze, and T-maze devices to evaluate the spatial learning and memory competence. Neurotransmitters and oxidative indices in the forebrain were estimated. According to behavioral studies, the male animals from the Ag-NP group presented worse memory than those in the control group. The biochemical changes after Ag-NP exposure were observed through increasing TBARS levels and decline in oxidative biomarkers (SOD, CAT, GST, and GSH) and neurotransmitters (DOP, SER, and AChE) in the forebrain of male mice compared to untreated animals. Interestingly, the animals treated with mixed doses of Ag-NPs and YO-NPs displayed improvements in behavioral tests, oxidative parameters, and neurotransmitters compared to males treated with Ag-NPs alone. In conclusion, the abnormal behavior related to learning and memory in male mice induced by Ag-NPs was significantly alleviated by YO-NPs. Specifically, the coinjection of YO-NPs with Ag-NPs moderates the disruption in neurotransmitters, oxidative indices of mice brains, which reflects on their cognitive behaviors.
Funder
Imam Abdulrahman Bin Faisal University
Subject
Cell Biology,Aging,General Medicine,Biochemistry
Cited by
2 articles.
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