Production of Nitric Oxide and Expression of Inducible Nitric Oxide Synthase in Ovarian Cystic Tumors

Author:

Nomelini Rosekeila Simões12,Ribeiro Lívia Carolina de Abreu3,Tavares-Murta Beatriz Martins3,Adad Sheila Jorge4,Murta Eddie Fernando Candido1

Affiliation:

1. Research Institute of Oncology (IPON), Discipline of Gynecology and Obstetrics, Federal University of Triângulo Mineiro, 38025-440 Uberaba, MG, Brazil

2. Discipline of Human Anatomy, Federal University of Triângulo Mineiro, 38025-440 Uberaba, MG, Brazil

3. Discipline of Pharmacology, Federal University of Triângulo Mineiro, 38015-050 Uberaba, MG, Brazil

4. Discipline of Special Pathology, Federal University of Triângulo Mineiro, 38025-440 Uberaba, MG, Brazil

Abstract

Tumor sections from nonneoplastic (n=15), benign (n=28), and malignant ovarian tumors (n=20) were obtained from 63 women. Immunohistochemistry of the tumor sections demonstrated that inducible nitric oxide synthase (iNOS) expression was increased in ovarian cancer samples compared to nonneoplastic or benign tumor samples. Using the Griess method, nitric oxide (NO) metabolite levels were also found to be elevated in malignant tumor samples compared to benign tumor samples (P<.05). For stage I ovarian cancer, intracystic NO levels>80μMwere more frequent than NO levels<80μM, and iNOS expression in well-differentiated carcinomas was greater than in moderately/poorly differentiated carcinomas (P<.05). These data suggest an important role for NO in ovarian carcinogenesis.

Funder

Conselho Nacional de Desenvolvimento Científico e Tecnológico

Publisher

Hindawi Limited

Subject

Cell Biology,Immunology

Cited by 19 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3