Resveratrol Attenuates Learning, Memory, and Social Interaction Impairments in Rats Exposed to Arsenic

Abstract

Arsenic (As) toxicity has deleterious effects on human health causing disorder in the brain. The aim of this study was to investigate the possible neuroprotective effect of resveratrol (RSV) on arsenic-induced neurotoxicity in rats. Neurotoxicity in rats was developed by treating As 10 mg/kg/day for 21 days orally. Animals were put into seven groups: control, vehicle, As, As+RSV10, As+RSV20 mg/kg, RSV10, and RSV20 mg/kg. Behavioral assessments such as the social interaction test, novel object recognition test, elevated plus maze, open field, the Morris water maze, in addition to assessment of biomarkers such as ferric reducing ability of plasma assay, glutathione assay, and malondialdehyde assay, were used to evaluate the effects of RSV on cognitive impairment and molecular changes induced by As. The results showed that cognitive performance impaired in As rats. RSV20 mg/kg significantly could ameliorate behavioral changes like spatial learning in days 3 and 4 ( $p<0.05$ ), recognition learning and memory ( $p<0.01$ ), disabilities in motor coordination and stress ( $p<0.05$ ), increased anxiety ( $p<0.05$ ), and social interaction deficit (sociability ( $p<0.001$ ) and social memory ( $p<0.05$ )). RSV20 mg/kg also attenuated molecular modifications like decreased antioxidant power ( $p<0.001$ ), reduced glutathione content ( $p<0.05$ ), and increased malondialdehyde level ( $p<0.05$ ) induced by As. In addition to oxidative stress assessments, RSV10 mg/kg could significantly increase FRAP ( $p<0.01$ ) and GSH ( $p<0.05$ ); however, MDA was not significantly increased. Our current behavioral findings suggest that RSV has neuroprotective effects against AS toxicity.