The S100B/RAGE Axis in Alzheimer's Disease-Reference-Cited by-同舟云学术

The S100B/RAGE Axis in Alzheimer's Disease

Published:2010-06-21 Issue: Volume:2010 Page:1-11
ISSN:2090-0163
Container-title:Cardiovascular Psychiatry and Neurology
language:en
Short-container-title:Cardiovascular Psychiatry and Neurology

Author:

Leclerc Estelle¹^ORCID,Sturchler Emmanuel²,Vetter Stefan W.¹

Affiliation:

1. Department of Pharmaceutical Sciences, North Dakota State University, Dept. 2665, P.O. Box 6050, Fargo, ND 58108-6050, USA

2. Department of Drug Discovery, The Scripps Research Institute, 130 Scripps Way, Jupiter, FL 33458, USA

Abstract

Increasing evidence suggests that the small EF-hand calcium-binding protein S100B plays an important role in Alzheimer's disease. Among other evidences are the increased levels of both S100B and its receptor, the Receptor for Advanced Glycation Endproducts (RAGEs) in the AD diseased brain. The regulation of RAGE signaling by S100B is complex and probably involves other ligands including the amyloid beta peptide (A), the Advanced Glycation Endproducts (AGEs), or transtheyretin. In this paper we discuss the current literature regarding the role of S100B/RAGE activation in Alzheimer's disease.

Publisher

Hindawi Limited

Subject

Psychiatry and Mental health,Cardiology and Cardiovascular Medicine,Clinical Neurology,Neurology

Link

http://downloads.hindawi.com/archive/2010/539581.pdf

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