Affiliation:
1. Chemistry Department, National University of Ireland Maynooth, Maynooth, Co.m, Kildare, Ireland
2. Dublin Institute of Technology, Cathal Brugha Street, Dublin, Ireland
3. Biochemistry Department, Trinity College, Dublin, Ireland
Abstract
Metal complexes of malonie acid (metal = Mn(II), Co(II), Ni(II), Cu(II), Zn(II), Ag(I)) were
prepared and only the Ag(I) complex inhibited the growth of Candida albicans. Malonate complexes
incorporating the chelating 1,10-phenanthroline (1,10-phen) ligand showed a range of activities: good
(Mn(II), Cu(II), Ag(I)); moderate (Zn(II)); poor (Co(II), Ni(II)). Metal-free 1,10-phen and Ag(CH3CO2)
were also highly active. The metal-free non-chelating ligands 1,7- phenanthroline and 4,7-phenanthroline
were inactive and the Cu(II), Mn(II) and Zn(II) complexs of 1,7-phen displayed only marginal activity.
Whereas the Cu(II) malonate/1,10-phen complex induces significant cellular oxidative stress the Zn(II)
analogue does not.
Subject
Inorganic Chemistry,Drug Discovery,Pharmacology,Toxicology
Cited by
99 articles.
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