Relationship between Urinary AD7c-NTP with Cerebral Microbleeds Based on APOE Genotype

Abstract

Objective. This study was performed to investigate the association between urinary Alzheimer-associated neuronal thread protein (AD7c-NTP) with cerebral microbleeds (CMBs) based on the apolipoprotein E (APOE) genotypes. Methods. A total of 471 patients with acute cerebral infarction screened by magnetic sensitive imaging were enrolled in this study. Among them, twenty-seven cases of mixed CMBs were excluded. A total of 444 patients were divided into two groups according to the presence or absence of CMBs: CMBs group ( $n=92$ ) and noncerebral microbleeds group (nCMBs) ( $n=352$ ). Urine AD7c-NTP levels were measured using a human enzyme immunoassay kit. Results. In patients with lobar CMBs, there was an interaction between urine AD7c-NTP levels and APOE genotypes ( $p=0.01$ ). In patients with APOE ε3/ε3 allele, the odds ratio of lobar CMBs per standard deviation of urinary AD7c-NTP levels was 0.92 (95% CI: 0.70-1.19). In patients with APOE ε2+ or ε4+ allele, the multivariate-corrected odds ratio of lobar CMBs per standard deviation of urinary AD7c-NTP levels was 2.95 (95% CI: 1.38-6.27). Conclusion. A higher level of urinary AD7c-NTP is involved in lobar CMBs, not deep CMBs.