Harmful Effects of Synthetic Surface-Active Detergents against Atopic Dermatitis-Reference-Cited by-同舟云学术

Harmful Effects of Synthetic Surface-Active Detergents against Atopic Dermatitis

Published:2015 Issue: Volume:2015 Page:1-5
ISSN:2090-6463
Container-title:Case Reports in Dermatological Medicine
language:en
Short-container-title:Case Reports in Dermatological Medicine

Author:

Deguchi Hajime¹²,Aoyama Riho¹²,Takahashi Hideaki¹²,Isobe Yoshinari³,Tsutsumi Yutaka²

Affiliation:

1. Fujita Health University School of Medicine, Toyoake, Aichi 470-1192, Japan

2. Department of Pathology, Fujita Health University School of Medicine, Toyoake, Aichi 470-1192, Japan

3. Isobe Clinic, Anjo, Aichi 446-0026, Japan

Abstract

We report herein two cases of intractable atopic dermatitis successfully treated by simply avoiding the contact with surface-active detergents in the daily life and living. The detergents were closely related to the exacerbation and remission of the disease. Steroid ointment was no longer used. We discuss that the removal of horny layer lipids by surface-active detergents accelerates the transepidermal water loss and disturbs the barrier function of the epidermis and thus is intimately involved in the pathogenesis of atopic dermatitis.

Publisher

Hindawi Limited

Subject

Dermatology

Link

http://downloads.hindawi.com/journals/cridm/2015/898262.pdf

Reference18 articles.

1. Atopic Dermatitis

2. Epidermal Barrier Dysfunction in Atopic Dermatitis

3. Atopic dermatitis: a disease of altered skin barrier and immune dysregulation

4. Guidelines for management of atopic dermatitis

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