Association of Thrombomodulin Gene C1418T Polymorphism with Susceptibility to Kawasaki Disease in Chinese Children-Reference-Cited by-同舟云学术

Association of Thrombomodulin Gene C1418T Polymorphism with Susceptibility to Kawasaki Disease in Chinese Children

Published:2018-06-12 Issue: Volume:2018 Page:1-5
ISSN:0278-0240
Container-title:Disease Markers
language:en
Short-container-title:Disease Markers

Author:

Lu Yapeng¹,Liu Rui¹,Zha Luting¹,Yuan Shan¹,Tian Lang¹,Chen Jia¹,Huang Lihua²,Yang Zuocheng¹^ORCID

Affiliation:

1. Department of Pediatrics, The Third Xiangya Hospital of Central South University, Changsha, Hunan 410013, China

2. Central Laboratory, The Third Xiangya Hospital of Central South University, Changsha, Hunan 410013, China

Abstract

Kawasaki disease (KD) is an acute systemic vasculitis that predominantly affects children and can result in coronary artery lesions (CALs). Thrombomodulin (TM) is a critical cofactor in the protein C anticoagulant system. The TM C1418T (rs1042579) polymorphism is associated with a high risk of cardiac-cerebral vascular diseases. But the association of the TM C1418T polymorphism with susceptibility to KD, CAL formation, and intravenous immunoglobulin (IVIG) resistance is still unclear. In our study, we examined the TM C1418T polymorphism in 122 children with KD and 126 healthy children and revealed the correlation between the TM C1418T polymorphism and KD, CAL formation, and IVIG resistance.

Funder

Central South University

Publisher

Hindawi Limited

Subject

Biochemistry (medical),Clinical Biochemistry,Genetics,Molecular Biology,General Medicine

Link

http://downloads.hindawi.com/journals/dm/2018/1064380.pdf

Reference22 articles.

1. Update on Kawasaki disease: Epidemiology, aetiology and pathogenesis

2. Recent Advances in Kawasaki Disease

3. The epidemiology of Kawasaki disease: a global update