Possible Epigenetic Role of Vitexin in Regulating Neuroinflammation in Alzheimer’s Disease

Author:

Yahaya M. A. F.1ORCID,Zolkiffly S. Z. I.1,Moklas M. A. M.1ORCID,Hamid H. Abdul1,Stanslas J.2ORCID,Zainol M.3,Mehat M. Z.1ORCID

Affiliation:

1. Department of Human Anatomy, Faculty of Medicine & Health Science, Universiti Putra Malaysia, 43400 Serdang, Selangor, Malaysia

2. Department of Medicine, Faculty of Medicine & Health Science, Universiti Putra Malaysia, 43400 Serdang, Selangor, Malaysia

3. Herbal Medicine Research Centre, Institute for Medical Research, Jalan Pahang, Kuala Lumpur, Malaysia

Abstract

Alzheimer’s disease (AD) has been clinically characterized by a progressive degeneration of neurons which resulted in a gradual and irreversible cognitive impairment. The accumulation of Aβandτproteins in the brain contribute to the severity of the disease. Recently, vitexin compound has been the talk amongst researchers due to its pharmacological properties as anti-inflammation and anti-AD. However, the epigenetic mechanism of the compound in regulating the neuroinflammation activity is yet to be fully elucidated. Hence, this review discusses the potential of vitexin compound to have the pharmacoepigenetic property in regulating the neuroinflammation activity in relation to AD. It is with hope that the review would unveil the potential of vitexin as the candidate in treating AD.

Funder

Universiti Putra Malaysia

Publisher

Hindawi Limited

Subject

Immunology,General Medicine,Immunology and Allergy

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