A Case of Severe Asthma with Eosinophilic Otitis Media Successfully Treated with Anti-IgE Monoclonal Antibody Omalizumab-Reference-Cited by-同舟云学术

A Case of Severe Asthma with Eosinophilic Otitis Media Successfully Treated with Anti-IgE Monoclonal Antibody Omalizumab

Published:2012 Issue: Volume:2012 Page:1-5
ISSN:2090-6846
Container-title:Case Reports in Pulmonology
language:en
Short-container-title:Case Reports in Pulmonology

Author:

Okude Azusa¹,Tagaya Etsuko¹,Kondo Mitsuko¹,Nonaka Manabu²,Tamaoki Jun¹

Affiliation:

1. First Department of Medicine, School of Medicine, Tokyo Women’s Medical University, 8-1 Kawada-Cho, Shinjuku-ku, Tokyo 162-8666, Japan

2. Department of Otolaryngology, School of Medicine, Tokyo Women’s Medical University, 8-1 Kawada-Cho, Shinjuku-ku, Tokyo 162-8666, Japan

Abstract

A 51-year-old woman had been receiving medical treatment for asthma since she was 21 years old. However, her asthma was poorly controlled despite treatment involving combination inhalation of high-dose corticosteroid and long-actingβ2-aderenergic agonist (LABA) and regularly taking oral steroids. Hearing loss and otorrhea appeared at the age of 44, and she was given a diagnosis of eosinophilic otitis media (EOM) and received medical treatment. In 2007, symptoms of asthma and otitis media deteriorated. In December 2009, omalizumab therapy was started for refractory asthma. After 2 months of omalizumab treatment, not only asthma, but also hearing loss improved. It is suggested that early initiation of omalizumab therapy may inhibit the progression of progressive EOM.

Publisher

Hindawi Limited

Subject

Pulmonary and Respiratory Medicine

Link

http://downloads.hindawi.com/journals/cripu/2012/340525.pdf

Reference7 articles.

1. The anti-inflammatory effects of omalizumab confirm the central role of IgE in allergic inflammation

2. Diagnostic criteria of eosinophilic otitis media, a newly recognized middle ear disease

3. Eosinophils are activated in middle ear mucosa and middle ear effusion of patients with intractable otitis media associated with bronchial asthma

4. IL-5 and Eotaxin Levels in Middle Ear Effusion and Blood from Asthmatics with Otitis Media with Effusion

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