High Expression of GSDMC Is Associated with Poor Survival in Kidney Clear Cell Cancer-Reference-Cited by-同舟云学术

High Expression of GSDMC Is Associated with Poor Survival in Kidney Clear Cell Cancer

Published:2021-11-05 Issue: Volume:2021 Page:1-10
ISSN:2314-6141
Container-title:BioMed Research International
language:en
Short-container-title:BioMed Research International

Author:

Cui Yun-Qian¹^ORCID,Meng Fei¹^ORCID,Zhan Wen-Li¹^ORCID,Dai Zhou-Tong²^ORCID,Liao Xinghua²^ORCID

Affiliation:

1. School of Bioengineering, Qilu University of Technology (Shandong Academy of Sciences), Jinan 250353, China

2. Institute of Biology and Medicine, College of Life and Health Sciences, Wuhan University of Science and Technology, Hubei 430081, China

Abstract

This study is aimed at exploring the potential role of GSDMC in kidney renal clear cell carcinoma (KIRC). We analyzed the expression of GSDMC in 33 types of cancers in TCGA database. The results showed that the expression of GSDMC was upregulated in most cancers. We found a significant association between high expression of GSDMC and shortened patient overall survival, progression-free survival, and disease-specific survival. In vitro experiments have shown that the expression of GSDMC was significantly elevated in KIRC cell lines. Moreover, decreased expression of GSDMC was significantly associated with decreased cell proliferation. In summary, we believe that this study provides valuable data supporting future clinical treatment.

Funder

Natural Science Foundation of Shandong Province

Publisher

Hindawi Limited

Subject

General Immunology and Microbiology,General Biochemistry, Genetics and Molecular Biology,General Medicine

Link

http://downloads.hindawi.com/journals/bmri/2021/5282894.pdf

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