Effect of Aging on NK Cell Population and Their Proliferation at Ex Vivo Culture Condition

Author:

Gounder Sellamuthu Subbanna1,Abdullah Basri Johan Jeet2,Radzuanb Nur Ezzati Izyan Binti Mohd1,Zain Farah Dalila Binti Mohd1,Sait Nurhidayah Bt Mohamad1,Chua Corine2,Subramani Baskar1ORCID

Affiliation:

1. Nichi-Asia Life Science Sdn. Bhd., No. 57, Block F, Jalan Teknologi 3/9, Bistari De Kota, Kota Damansara, PJU 5, 47810 Petaling Jaya, Selangor, Malaysia

2. Department of Biomedical Imaging, University of Malaya, 50603 Kuala Lumpur, Malaysia

Abstract

Age-associated changes in natural killer (NK) cell population, phenotype, and functions are directly attributed to the risk of several diseases and infections. It is predicted to be the major cause of the increase in mortality. Based on the surface density of CD56, NK cells are subdivided into two types, such as CD56brightand CD56dimcells, which represent cytokine production and cytotoxicity. In our study, we have examined the age-associated changes in the NK cell population and their subsets at different age groups of males and females (at a range from 41 to 80 years). We found that the total lymphocyte count significantly dropped upon aging in both genders. Although, the level of total immune cells also dropped on aging, and surprisingly the total NK cell population was remarkably increased with the majority of NK cells being CD56dim. Subsequently, we evaluated the proliferation potential of NK cells and our results showed that the NK cell proliferation ability declines with age. Overall, our findings prove that there is an increase in the circulating NK cell population upon aging. However, the proliferation rate upon aging declines when compared to the young age group (<41 yrs).

Publisher

Hindawi Limited

Subject

Cancer Research,Cell Biology,Molecular Medicine,General Medicine,Pathology and Forensic Medicine

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