Melanonychia

Author:

Jefferson Julie1ORCID,Rich Phoebe1

Affiliation:

1. Oregon Health and Science University, Portland, OR, USA

Abstract

Melanonychia, or melanin-derived brown-to-black nail pigmentation, is a diagnostic challenge for clinicians. The most serious disease of the nail unit, melanoma, primarily presents with melanonychia. However, melanonychia most often occurs as a result of benign etiologies such as nail matrix melanocytic activation, nail matrix melanocytic hyperplasia, and nail invasion by melanin-producing pathogens. Regrettably, patients with nail apparatus melanoma are often initially misdiagnosed, and due to diagnostic delays of an average of 2 years, melanoma of the nail unit carries a poor prognosis. Having a thorough knowledge of the various causes of melanonychia and using a systematic approach when evaluating brown-to-black nail pigmentation may help prevent misdiagnosis and thereby improve prognosis.

Publisher

Hindawi Limited

Subject

Dermatology

Cited by 57 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

1. Hair Versus Nails: Is There a Place for Other Keratin Matrices?;Perspectives and Challenges of Hair Analysis;2023-12-18

2. Seven Plus One Steps to Assess Pigmented Nail Bands (Melanonychia Striata Longitudinalis);Dermatology Practical & Conceptual;2023-10-31

3. Reticular melanonychia: a dermoscopic clue for terra firma-forme dermatosis on the nails;Clinical and Experimental Dermatology;2023-07-05

4. Disorders of hyperpigmentation. Part I. Pathogenesis and clinical features of common pigmentary disorders;Journal of the American Academy of Dermatology;2023-02

5. Postinflammatory pigmentation and friction melanonychia;International Journal of Dermatology;2023-01-22

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