Type 2 Innate Lymphoid Cells: Friends or Foes—Role in Airway Allergic Inflammation and Asthma-Reference-Cited by-同舟云学术

Type 2 Innate Lymphoid Cells: Friends or Foes—Role in Airway Allergic Inflammation and Asthma

Published:2012-11-11 Issue: Volume:2012 Page:1-13
ISSN:1687-9783
Container-title:Journal of Allergy
language:en
Short-container-title:Journal of Allergy

Author:

Pishdadian Abbas¹^ORCID,Varasteh Abdol-Reza²,Sankian Mojtaba¹

Affiliation:

1. Immunology Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

2. Immuno-Biochemistry Lab, Allergy Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

Abstract

Innate-like lymphocytes (ILLs) and innate lymphoid cells (ILCs) are two newly characterized families of lymphocytes with limited and no rearranged antigen receptors, respectively. These soldiers provide a first line of defense against foreign insults by triggering a prompt innate immune response and bridging the gap of innate and adaptive immunity. Type 2 innate lymphoid cells (ILCs2) are newly identified members of the ILC family that play a key role in type 2 immune responses by prompt production of type 2 cytokines (especially IL-5 and IL-13) in response to antigen-induced IL-25/33 and by recruiting type 2 “immune franchise.” Regarding the two different roles of type 2 cytokines, helminth expulsion and type 2-related diseases, here we review the latest advances in ILC2 biology and examine the pivotal role of resident ILCs2 in allergen-specific airway inflammation and asthma.

Publisher

Hindawi Limited

Subject

Immunology and Allergy

Link

http://downloads.hindawi.com/archive/2012/130937.pdf

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