Antioxidant and Antibacterial Activities of Silver Nanoparticles Biosynthesized by Moringa oleifera through Response Surface Methodology

Author:

Mohammed A. B. Abeer1,Mohamed Amr1,El-Naggar Noura El-Ahmady2ORCID,Mahrous Hoda3,Nasr Ghada M.4,Abdella Asmaa3,Ahmed Rasha H.5ORCID,Irmak Sibel6,Elsayed Mohamed S. A.7,Selim Samy8ORCID,Elkelish Amr9ORCID,Alkhalifah Dalal Hussien M.10,Hozzein Wael N.11ORCID,Ali Abdallah S.5ORCID

Affiliation:

1. Department of Microbial Biotechnology, Genetic Engineering and Biotechnology Research Institute, University of Sadat City, Egypt

2. Department of Bioprocess Development, Genetic Engineering and Biotechnology Research Institute, City of Scientific Research and Technological Applications (SRTA-City), New Borg El Arab City, 21934 Alexandria, Egypt

3. Department of Industrial Biotechnology, Genetic Engineering and Biotechnology Research Institute, University of Sadat City, Egypt

4. Department of Molecular Diagnostics, Genetic Engineering and Biotechnology Research Institute, University of Sadat City, Egypt

5. Department of Microbiology, Faculty of Agriculture, Cairo University, 12613 Giza, Egypt

6. Department of Agricultural and Biological Engineering, Pennsylvania State University, University Park, PA 16802, USA

7. Department of Bacteriology, Mycology, and Immunology, Faculty of Veterinary Medicine, University of Sadat City, Menoufia 32897, Egypt

8. Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, Jouf University, Sakaka, 72388, Saudi Arabia

9. Botany Department, Faculty of Science, Suez Canal University, Ismailia, Egypt

10. Department of Biology, College of Science, Princess Nourah Bint Abdulrahman University, P.O. Box 84428, Riyadh 11671, Saudi Arabia

11. Botany and Microbiology Department, Faculty of Science, Beni-Suef University, Beni-Suef, Egypt

Abstract

The research highlights the environmentally sustainable biosynthesis of silver nanoparticles from fresh leaves of the herbal medicinal plant Moringa oleifera. They may have been used as anti-inflammatory, anticancer, and antimicrobial agents. M. oleifera extract both reduces and stabilizes silver nanoparticles (AgNPs). Optimum factors needed for AgNP biosynthesis were studied using a central composite design (CCD) matrix. Ultraviolet-visible (UV–Vis) absorption spectroscopy, transmission electron microscopy, and Fourier-transform infrared spectroscopy were used to confirm and characterize the synthesized AgNPs. The biogenic AgNPs demonstrated substantial antibacterial potential against the pathogenic strains Escherichia coli, Klebsiella pneumoniae, Staphylococcus aureus, and Bacillus subtilis. The antioxidant activity of biosynthesized AgNPs with M. oleifera extract increased from 11.96% when the concentration of the extract was 4 mg/mL to 63.79% at a plant concentration of 20 mg/mL. This research provides an easy and cost-effective technique for the production of stable nanoparticles, with an evaluation of their bioactivity.

Funder

Cairo University

Publisher

Hindawi Limited

Subject

General Materials Science

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