New Acetylcholinesterase Inhibitors for Alzheimer's Disease

Author:

Mehta Mona1,Adem Abdu2,Sabbagh Marwan1

Affiliation:

1. The Cleo Roberts Center for Clinical Research, Banner Sun Health Research Institute, 10515 W Santa Fe Dr, Sun City, AZ 85351, USA

2. Department of Pharmacology and Therapeutics, United Arab Emirates University, Al Ain, UAE

Abstract

Acetylcholinesterase (AChE) remains a highly viable target for the symptomatic improvement in Alzheimer's disease (AD) because cholinergic deficit is a consistent and early finding in AD. The treatment approach of inhibiting peripheral AchE for myasthenia gravis had effectively proven that AchE inhibition was a reachable therapeutic target. Subsequently tacrine, donepezil, rivastigmine, and galantamine were developed and approved for the symptomatic treatment of AD. Since then, multiple cholinesterase inhibitors (ChEI) continue to be developed. These include newer ChEIs, naturally derived ChEIs, hybrids, and synthetic analogues. In this paper, we summarize the different types of ChEIs in development and their respective mechanisms of actions. This pharmacological approach continues to be active with many promising compounds.

Funder

National Institute on Aging

Publisher

Hindawi Limited

Subject

Behavioral Neuroscience,Cellular and Molecular Neuroscience,Cognitive Neuroscience,Clinical Neurology,Neurology,Ageing

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