Aqueous Extract of Sparganii Rhizoma and Curcumae Rhizoma Induces Apoptosis and Inhibits Migration in Human Oral Squamous Cell Carcinoma

Author:

Chang Kai-Wei12,Wu Chia-Yu34,Renn Ting-Yi5,Chang Tsung-Ming6ORCID,Wei Augusta I-Chin7,Kung Yen-Ying128ORCID,Liu Ju-Fang7910ORCID

Affiliation:

1. Institute of Traditional Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan

2. Center for Traditional Medicine, Taipei Veterans General Hospital, Taipei, Taiwan

3. School of Dental Technology, College of Oral Medicine, Taipei Medical University, Taipei, Taiwan

4. Division of Oral and Maxillofacial Surgery, Department of Dentistry, Taipei Medical University Hospital, Taipei, Taiwan

5. Department of Oral and Maxillofacial Pathobiology, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan

6. Institute of Physiology, School of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan

7. Translational Medicine Center, Shin-Kong Wu Ho-Su Memorial Hospital, Taipei, Taiwan

8. Faculty of Medicine, School of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan

9. School of Oral Hygiene, College of Oral Medicine, Taipei Medical University, Taipei, Taiwan

10. Department of Medical Research, China Medical University Hospital, China Medical University, Taichung, Taiwan

Abstract

Sparganii Rhizoma and Curcumae Rhizoma (SRCR) are natural herbs used in traditional Chinese medicine to treat tumors and activate blood circulation. Previous studies have shown that SRCR possesses notable antitumor activity; however, the mechanism underlying anticancer activity in human oral squamous cell carcinoma (OSCC) has yet to be fully elucidated. The risk factors of OSCC include smoking, alcohol consumption, poor oral hygiene, and human papillomavirus infection. OSCC is highly metastatic and responds poorly to chemotherapy; thus, alternative treatment options are imperative. In this study, we found that SRCR induced death in OSCC cells but not in normal cells (HGF-1 cells). SRCR has also shown to induce the production of reactive oxygen species in OSCC cells, sequentially promoting calcium release and stress in the endoplasmic reticulum, which resulted in mitochondrial dysfunction and subsequent apoptosis. Furthermore, SRCR has shown to inhibit the migration of OSCC cells by reducing matrix metalloproteinase-12 and -13. Our findings demonstrate that SRCR exerts anticancer activities in OSCC by inducing cell apoptosis and suppressing cell migration.

Funder

Ministry of Science and Technology, Taiwan

Publisher

Hindawi Limited

Subject

Cell Biology,Pharmacology,Food Science,Biophysics

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