The Role of MicroRNAs in Regulating Cytokines and Growth Factors in Coronary Artery Disease: The Ins and Outs

Author:

Gorabi Armita Mahdavi1,Kiaie Nasim1,Sathyapalan Thozhukat2,Al-Rasadi Khalid3,Jamialahmadi Tannaz456,Sahebkar Amirhossein78910ORCID

Affiliation:

1. Research Center for Advanced Technologies in Cardiovascular Medicine, Tehran Heart Center, Tehran University of Medical Sciences, Tehran, Iran

2. Department of Academic Diabetes, Endocrinology and Metabolism, Hull York Medical School, University of Hull, Hull, UK

3. Medical Research Centre, Sultan Qaboos University, Muscat, Oman

4. Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran

5. Department of Food Science and Technology, Quchan Branch, Islamic Azad University, Quchan, Iran

6. Department of Nutrition, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

7. Halal Research Center of IRI, FDA, Tehran, Iran

8. Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad 9177948564, Iran

9. Neurogenic Inflammation Research Center, Mashhad University of Medical Sciences, Mashhad, Iran

10. School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran

Abstract

Coronary artery diseases (CAD), as a leading cause of mortality around the world, has attracted the researchers’ attention for years to find out its underlying mechanisms and causes. Among the various key players in the pathogenesis of CAD cytokines, microRNAs (miRNAs) are crucial. In this study, besides providing a comprehensive overview of the involvement of cytokines, growth factors, and miRNAs in CAD, the interplay between miRNA with cytokine or growth factors during the development of CAD is discussed.

Publisher

Hindawi Limited

Subject

Immunology,General Medicine,Immunology and Allergy

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