Static Magnetic Fields Modulate the Response of Different Oxidative Stress Markers in a Restraint Stress Model Animal

Author:

Coballase-Urrutia E.1ORCID,Navarro L.2ORCID,Ortiz J. L.3,Verdugo-Díaz L.2,Gallardo J. M.4,Hernández Maria Eugenia5ORCID,Estrada-Rojo F.2ORCID

Affiliation:

1. Laboratory of Neuroscience, National Institute of Pediatrics, 04539 Ciudad de México, Mexico

2. Physiology Department, Faculty of Medicine, UNAM, 04150 Ciudad de México, Mexico

3. Tominaga Nakamoto School of Medicine, 53390 Naucalpan de Juarez, MEX, Mexico

4. Laboratory of Nephrology Specialties Hospital, XXI Century National Medical Center, IMSS, 06720 Ciudad de México, Mexico

5. Laboratory of Neuropharmacology, Subdirection of Clinical Investigations, National Institute of Psychiatry “Ramón de la Fuente Muñiz”, 14370 Ciudad de México, Mexico

Abstract

Stress is a state of vulnerable homeostasis that alters the physiological and behavioral responses. Stress induces oxidative damage in several organs including the brain, liver, kidney, stomach, and heart. Preliminary findings suggested that the magnetic stimulation could accelerate the healing processes and has been an effective complementary therapy in different pathologies. However, the mechanism of action of static magnetic fields (SMFs) is not well understood. In this study, we demonstrated the effects of static magnetic fields (0.8 mT) in a restraint stressed animal model, focusing on changes in different markers of oxidative damage. A significant increase in the plasma levels of nitric oxide (NO), malondialdehyde (MDA), and advanced oxidation protein products (AOPP), and a decrease in superoxide dismutase (SOD), glutathione (GSH), and glycation end products (AGEs) were observed in restraint stress model. Exposure to SMFs over 5 days (30, 60, and 240 min/day) caused a decrease in the NO, MDA, AGEs, and AOPP levels; in contrast, the SOD and GSH levels increased. The response to SMFs was time-dependent. Thus, we proposed that exposure to weak-intensity SMFs could offer a complementary therapy by attenuating oxidative stress. Our results provided a new perspective in health studies, particularly in the context of oxidative stress.

Funder

PAPIIT

Publisher

Hindawi Limited

Subject

General Immunology and Microbiology,General Biochemistry, Genetics and Molecular Biology,General Medicine

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