Mucin Overproduction in Chronic Inflammatory Lung Disease-Reference-Cited by-同舟云学术

Mucin Overproduction in Chronic Inflammatory Lung Disease

Published:2006 Issue:6 Volume:13 Page:327-335
ISSN:1198-2241
Container-title:Canadian Respiratory Journal
language:en
Short-container-title:Canadian Respiratory Journal

Author:

Hauber Hans-Peter¹²,Foley Susan C¹,Hamid Qutayba¹

Affiliation:

1. Meakins-Christie Laboratories, McGill University, Montreal, Quebec, Canada

2. Department of Medicine, Research Center Borstel, Borstel, Germany

Abstract

Mucus overproduction and hypersecretion are commonly observed in chronic inflammatory lung disease. Mucins are gel-forming glycoproteins that can be stimulated by a variety of mediators. The present review addresses the mechanisms involved in the upregulation of secreted mucins. Mucin induction by neutrophil elastase, bacteria, cytokines, growth factors, smoke and cystic fibrosis transmembrane conductance regulator malfunction are also discussed.

Funder

Canadian Institutes of Health Research

Publisher

Hindawi Limited

Subject

Pulmonary and Respiratory Medicine

Link

http://downloads.hindawi.com/journals/crj/2006/901417.pdf

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