Prospects of IL-2 in Cancer Immunotherapy-Reference-Cited by-同舟云学术

Prospects of IL-2 in Cancer Immunotherapy

Published:2018 Issue: Volume:2018 Page:1-7
ISSN:2314-6133
Container-title:BioMed Research International
language:en
Short-container-title:BioMed Research International

Author:

Choudhry Hani¹^ORCID,Helmi Nawal¹^ORCID,Abdulaal Wesam H.¹,Zeyadi Mustafa¹,Zamzami Mazin A.¹,Wu Wei²,Mahmoud Maged Mostafa³⁴,Warsi Mohiuddin Khan⁵,Rasool Mahmood⁶,Jamal Mohammad S.³^ORCID

Affiliation:

1. Department of Biochemistry, Cancer Metabolism and Epigenetic Unit, Faculty of Science, Cancer and Mutagenesis Unit, King Fahd Center for Medical Research, King Abdulaziz University, Jeddah, Saudi Arabia

2. Department of Medicine, University of California, San Francisco, CA 94143, USA

3. King Fahd Medical Research, King Abdulaziz University, Jeddah, Saudi Arabia

4. Department of Molecular Genetics and Enzymology, Division of Human Genetics and Genome Research, National Research Center, Giza, Egypt

5. Department of Biochemistry, University of Jeddah, Jeddah, Saudi Arabia

6. Center of Excellence in Genomic Medicine Research, King Abdulaziz University, Jeddah, Saudi Arabia

Abstract

IL-2 is a powerful immune growth factor and it plays important role in sustaining T cell response. The potential of IL-2 in expanding T cells without loss of functionality has led to its early use in cancer immunotherapy. IL-2 has been reported to induce complete and durable regressions in cancer patients but immune related adverse effects have been reported (irAE). The present review discusses the prospects of IL-2 in immunotherapy for cancer.

Publisher

Hindawi Limited

Subject

General Immunology and Microbiology,General Biochemistry, Genetics and Molecular Biology,General Medicine

Link

http://downloads.hindawi.com/journals/bmri/2018/9056173.pdf

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