Potential of Novel EPO Derivatives in Limb Ischemia-Reference-Cited by-同舟云学术

Potential of Novel EPO Derivatives in Limb Ischemia

Published:2012 Issue: Volume:2012 Page:1-5
ISSN:2090-8016
Container-title:Cardiology Research and Practice
language:en
Short-container-title:Cardiology Research and Practice

Author:

Joshi Dhiraj¹^ORCID,Tsui Janice¹,Yu Rebekah¹,Shiwen Xu²,Selvakumar Sadasivam¹,Abraham David J.²,Baker Daryll M.¹

Affiliation:

1. Vascular Unit, Division of Surgery and Interventional Science, Royal Free Hospital, University College London (Royal Free Campus), Pond Street, London NW3 2QG, UK

2. Centre for Rheumatology, University College London (Royal Free Campus), Pond Street, London NW3 2QG, UK

Abstract

Erythropoietin (EPO) has tissue-protective properties, but it increases the risk of thromboembolism by raising the haemoglobin concentration. New generation of EPO derivatives is tissue protective without the haematopoietic side effects. Preclinical studies have demonstrated their effectiveness and safety. This paper summarizes the development in EPO derivatives with emphasis on their potential use in critical limb ischaemia.

Publisher

Hindawi Limited

Subject

Cardiology and Cardiovascular Medicine

Link

http://downloads.hindawi.com/journals/crp/2012/213785.pdf

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