Two Potential Biomarkers for the Diagnosis and Prognosis of Laryngeal Carcinoma: CCL20 and IL-17A

Abstract

This study is to uncover the possibilities of CCL20 and IL-17A to be potential hallmarks for laryngeal carcinoma. Relative levels of CCL20 and IL-17A in laryngeal carcinoma tissues were detected by quantitative real-time polymerase chain reaction (qRT-PCR). Correlation between CCL20 and IL-17A was analyzed by Pearson correlation test. Receiver operating characteristic (ROC) curves were depicted for assessing diagnostic values of CCL20 and IL-17A in laryngeal carcinoma. In addition, 98 laryngeal carcinoma patients were followed up for 5 years. Their follow-up data were utilized for assessing prognostic values of CCL20 and IL-17A. CCL20 and IL-17A were upregulated in laryngeal carcinoma tissues than those of normal ones. ROC curves identified diagnostic values of CCL20 ( $\text{AUC}=0.9719$ , $\text{cutoff}\text{value}=4.86$ , $\text{sensitivity}=98.98\%$ , $\text{specificity}=87.76\%$ ) and IL-17A ( $\text{AUC}=0.7965$ , $\text{cutoff}\text{value}=3.39$ , $\text{sensitivity}=71.31\%$ , $\text{specificity}=71.52\%$ ) in laryngeal carcinoma. Worse prognosis was observed in laryngeal carcinoma patients expressing high level of CCL20 or IL-17A. CCL20 and IL-17A are upregulated in laryngeal carcinoma tissues, which are unfavorable factors for the prognosis of laryngeal carcinoma. CCL20 and IL-17A are promising hallmarks of laryngeal carcinoma.